The assessment and management of pain in children with Guillain-Barré Syndrome in a sub-Saharan setting.

Introduction

The prevalence of moderate to severe pain in the paediatric hospital setting is high 1. Pain management and analgesia is often suboptimal due to lack of training and knowledge, negative attitudes towards analgesics, inappropriate assessment of pain and the lack of algorithms to guide clinical practice 2345. In Africa, there are additional challenges of access to facilities, affordability and sustained availability of medications. As a result, paediatric pain relief often falls short of World Health Organization standards 67. Neuropathic pain, is increasingly recognized to occur in children and reported in diseases such as complex regional pain syndrome, spinal injuries, postoperative neuropathic pain, cancer related neuropathies, human immunodeficiency virus (HIV) neuropathy, and autoimmune conditions such as Guillain-Barr Syndrome, or acute inflammatory demyelinating polyradiculoneuropathy (AIDP) 8910.

In Guillain-Barr Syndrome the sensory changes include pain and paresthesia. The pain experienced is both nociceptive and neuropathic and is documented in up to 80-90% of patients, of whom two-thirds are considered to be severe 11121314. The natural history is variable in children with a mean length of time to symptom free recovery of 67 days. Improved pain control impacts on overall patient care and the illness experience 1516. This is thought due to improved coping mechanisms, decreased stress and anxiety, improved capacity to deliver acute and longterm rehabilitation, all of which may reduce the length of hospital stay and overall illness duration.

There are no clear guidelines to manage neuropathic pain in children, which has led to anecdotal practices and polypharmacy 341718. Combination therapy and adjuvant therapies such as tricyclic antidepressants, antiepileptic drugs (AEDs), calcitonin and local anaesthetics are used in conjunction with United State Food and Drug Administration (FDA) approved analgesics 192021.

Whilst AEDs such as carbamazepine, gabapentin and pregabalin are used for pain control, there is a lack of class one studies 1920222324. Small study size trials support the efficacy and safety of these drugs as analgesics, and there are reports that they are at least as effective as opioids for neuropathic pain relief with the additional advantage of reducing opioid requirements 25262728. This study reviewed the trends in the assessment and management of pain in children admitted to a tertiary centre in sub-Saharan Africa with Guillain-Barr Syndrome.

Methods

This was an observational retrospective study of clinical practice from 1st January 2002 to 31st December 2012, based at the Red Cross War Memorial Children's Hospital (RCWMCH) in Cape Town, South Africa. This is a university affiliate tertiary teaching hospital. It is the largest children's hospital in sub-Saharan Africa. The centre offers specialist and sub-specialist care to the paediatric population from the Western Cape and wider afield. Children with GuillainBarr Syndrome are managed according to current standard recommended guidelines. Children are clinically assessed to have pain, typically based on parental, nursing and ancillary staff feedback, are prescribed paracetamol with tilidine as a rescue dose for breakthrough pain. As part of standard hospital policy morphine is used for moderate to severe pain.

Current practice in our centre for pain control of patients with Guillain-Barr Syndrome is the off-label use of the antiepileptic drugs, namely carbamazepine and gabapentin. Either agent is initiated following the diagnosis of GuillainBarr Syndrome when pain, or the perceived risk of pain, is present. The later relates to the child who cannot express that they are in pain, for example whilst they are ventilated, or if they have profound motor impairment. Carbamazepine is titrated up to a maximum of 10-15 mg/kg/day over 2 to 3 weeks and gabapentin up to 40mg/kg/day over 2 weeks. Maintenance dose is based on the point of apparent pain control. Treatment is weaned off over 2 weeks during the rehabilitation period or at the time of discharge, when pain is no longer a complaint. As such the baseline acute pain care for these children is standard (paracetamol, tilidine and morphine) and the variable adjuvant drug decided upon by the attending clinician is either carbamazepine or gabapentin. This allowed us to analyse the sample in three distinct groups: patients who received carbamazepine, patients who received gabapentin and those who received neither agent. The groups were compared for duration of documented pain, severity, length of hospital stay and outcome.

Inclusion criteria: Children admitted over the study period (January 2002 to December 2012) between 1 month and 12 years of age with a confirmed diagnosis of GuillainBarr Syndrome, based on history and clinical examination, cerebrospinal fluid (CSF) findings and special investigations (neuroimaging and or nerve conduction studies) 29.

Exclusion criteria: Acute flaccid paralysis (AFP) due to an alternative cause such as acute transverse myelitis or non-polio enterovirus infections. Also, the dual use of gabapentin and carbamazepine for maintenance pain control since this precluded comparison of the outcome results from a single intervention and study numbers proved too small for this category.

Data collected included patient demographics, disease pattern and course, standard and adjuvant analgesic interventions, and the severity of illness. The medical records were reviewed for documentation of the analysis of pain assessment either via a formal pain score (e.g. FLACC 30 or COMFORT 31) (Appendix A), as an annotation in the medical, nursing or rehabilitation staff medical records, or through the frequency of additional analgesic doses. Data was recorded from those children who underwent cerebrospinal fluid screening (CSF), nerve conduction studies and magnetic resonance imaging (MRI). Immediate outcomes were documented with regards to duration of stay and resolution of respiratory compromise. All data were captured using Epidata and was analyzed using Matlab Statistics program.

Results

Between 2002-2012, 84 patients were admitted to RCWMCH with Guillain-Barr syndrome. The group demographics are summarized in Table 1. Sixty-five (76%) of the children had symptoms of pain recorded in their medical records, predominantly by the rehabilitation therapists. However, the severity of the pain could not be quantified due to suboptimal assessment of the pain and inadequate use of objective pain rating tools. Pain rating tools were only used in 3 patients. More than half of patients had breakthrough pain (53%) reported in their folders with the majority of this documented in relation to physiotherapy sessions. A mean of 2.7 analgesics were used per patient. Other modalities to relieve pain were also used inconsistently and to a lesser extent. The characteristics of analgesic usage are demonstrated in Table 2.

The use of analgesics paracetamol, morphine and tilidine remained constant throughout the study period. annum ( Figure 1). Of 49 children, 20 received gabapentin, 27 carbamazepine and 2 subsequently received both agents separately. For the whole group there was no statistical difference in any of the clinical interventions between the two AED groups. The children treated with carbamazepine received a mean dose of 4.3mg/kg/day (range 1.5-10) for 31 days (range 5-75) and those who received gabapentin received 9.38mg/kg/day (range 3-15) for 47 days (range 7-123 days). Thirty-seven children did not receive regular prophylaxis with either AED, these children tended to have a shorter, less severe course (p=0.0001). CSF was performed on 79 of the 84 patients with abnormally raised protein in 53%. Nerve conductions studies were performed in 38 patients and were supportive of the diagnosis in the majority (95%). Twenty-five patients underwent spine MRI, 10 were normal and the remaining 15 had enhancement of the nerve roots. Neuroimaging was performed when there was diagnostic concern, such as for the children on artificial ventilation who were paralysed and could not be formally neurologically assessed.

Discussion

Pain measurement in children is difficult 1531. Pain assessment tools are not standardized and as this study illustrates, this forms a major barrier to real understanding of the degree of pain suffered by children and the efficacy of the interventions used to control the complications. Appendix A summaries the pain tools which could be considered in these children. The few validated tools are mostly used in acute settings and resource equipped settings 1532. These tools may be less reliable in an African setting due to ethnic variation and differences in beliefs. There are no observational tools developed for measuring neuropathic or chronic pain in children 93233. Self-reporting is considered the most reliable method, especially in the setting of chronic pain 323433. But children, especially manijky of those in this cohort, would be too young to selfreport, and those old enough may not be able to self-report for the initial period due to being sedated and/or ventilated 28. The autonomic dysfunction which occurs in patients with Guillain-Barr syndrome would be a significant confounding factor when considering pain rating tools that rely on physiological measures 28. Inadequate measurement and assessment of pain during the study period limits definitive or useful comment on the degree of pain experienced by these children.

Neuropathic pain is a difficult entity for a clinician to manage. More than half the patients in this study were prescribed either gabapentin or carbamazepine as adjuvant analgesics. From the modalities recorded there was no difference in the apparent efficacy or safety for either agent. Whilst there is slightly more data to support gabapentin, overall the evidence is limited for both, especially in children 2224. There are two class I studies assessing the efficacy of gabapentin in adults with GuillainBarr syndrome. The first reviewed 18 adults in a randomized, doubleblinded, placebo-controlled crossover study 25. In addition to a numerical pain score, the amount of adjuvant analgesia with fentanyl was used as a measure of pain control. The study period was for 7 days and a significant reduction in pain and adjuvant therapy was evident during the gabapentin periods. The second study reviewed 36 adults with GuillainBarr Syndrome in a randomized, prospective, double-blinded, placebocontrolled study for patients in an intensive care setting who were ventilated 26. Patients were allocated to receive gabapentin, carbamazepine or placebo. The group concluded that both AEDs were more effective than placebo and that gabapentin was more effective than carbamazepine for decreasing pain and the need for adjuvant analgesia. Cohort sizes and duration of intervention were limiting factors for both these studies. The systematic review by Pena et al concluded that there was no robust evidence to recommend a single treatment option to manage pain in people with Guillain-Barr Syndrome 23. The group supported the need for further clinical studies with larger numbers, longer duration of monitoring and more effective measures to document intensity of pain objectively 23. A Cochrane review also could not conclude that there was sufficient evidence to support use of a specific pharmacological intervention, the follow-up meta-analysis 2 years later conclude the same 2435. The authors concluded that whilst reductions in pain severity were evident with both gabapentin and carbamazepine compared to placebo, the evidence for this remained limited and of low quality, further highlighting the need for larger, well designed randomised controlled trials.

Carbamazepine is associated with adverse effects related to its toxic metabolite and drug-drug interactions 36. In the sub-Saharan setting due to the high prevalence of HIV, carbamazepine is ideally avoided in combination with antiretroviral therapy to avoid AED toxicity and HIV treatment failure 37. In this setting, Gabapentin has a more favourable pharmacokinetic profile as it has an equivalent bioavailability to carbamazepine, is excreted unchanged via the kidneys, does not induce cytochrome p450, has fewer drug interactions and an overall better side effect profile 38.

Gabapentin is approved by the FDA for use in postherpetic neuralgia and focal epilepsy, off-label usage in both adult and paediatric practice has extended to various neuropathic pain conditions such as complex regional pain syndrome, post-operative neuralgia, burns, neuropathies related to cancer and HIV, and autoimmune syndromes such as GuillainBarr Syndrome 39. Despite the lack of class I evidence, the usage of gabapentin on and off-label has increased. The increasing trends of gabapentin usage in this study occurred due to clinicians' personal preference. The widely accepted anecdotal support of gabapentin needs more data to support a stronger recommendation for use.

Conclusion

This study draws to light two important issues. Firstly, the need for improvement and education in the use of standardized, objective and reproducible tools to rate pain on a regular basis in patients with GuillainBarr Syndrome. Secondly, with the increase of the use of gabapentin to control pain associated with Guillain-Barr Syndrome in children in our setting, the safety and efficacy needs to be established in comparison to other AEDs such as carbamazepine and pregabalin. This information will be vital in generating guidelines and protocols for pain management in various painful conditions and will in turn improve the way that we manage children experiencing pain with Guillain-Barr Syndrome.

Aknowledgments

From 2002 until 2008 all patients with documented pain were prescribed carbamazepine but from 2009 gabapentin was the preferred agent, and almost completely replaced car- bamazepine. From 2009, the overall trend of gabapentin usage was dramatic with an average increase of 73% per

Number of times each analgesic initiated per annum for children with Guillain-Barre Syndrome.

Ethical approval was obtained by the University of Cape Town's Human Research Ethics Committee (Ref no:231/2013).

Demographics of patients admitted to RCWMCH with GBS from 2002-2012CharacteristicResult Total Carbamazepine Gabapentin Neither Carbamazepine nor Gabapentin P value n = 84 n = 27 n = 20 n = 37 Age (median) 52 42 months range: 60 42 months range: [8-144] 48 35 months range: [13-138] 52 35 months range: [11-144] 0.41 Male:Female (percentage ratio) 50:50 45:55 55:45 51:49 - Length of hospital stay (median days) 14 43 range = [2-121] 45 33 range = [5-119] 48 36 range = [8-121] 10 15 range = [2-90] 0.85 Proportion needing ICU 41% 59% 64% 17% 0.62 Length of ICU stay (median days) 21,5 33 range = [1-83] 31 24 range = [1-83] 26 24 range = [1-83] 15 30 range = [2-75] 0.18 Proportion needing ventilator support 31% 52% 50% 8% 0.87 Proportion needing a tracheostomy 28% 52% 45% 1% 0.62 Table 2 Characteristics of pain assessment and analgesic usage Pain characteristic Total Study Results Carbamazepine Gabapentin Neither Carbamazepine nor Gabapentin P value * Number of patients n=84 n=27 n=20 n=37 Number of patients with documented pain 76% (n= 65) 86% (n= 24) 100% (n= 21) 54% (n= 20) 0.67 Pain rating tools used FLACC scale (2), Visual Analogue (1) 3% (n= 1) Visual Analogue 14% (n= 2) FLACC scale (2) 0% (n= 0) - Mean number analgesics used 2.3 1.8 range = [0-9] 3.2 0.8 range = [2-5] 3.2 0.8 range = [2-5] 1.2 2.1 range = [0-9] 0.76 Duration pain documented (median days) 4 8 range = [0-59] 13.4 12 range = [2-56] 12.7 13.4 range = [2-59] 4.2 4.2 range = [1-20] 0.9 Number of patients experiencing breakthrough pain 55% (n= 47) 79% (n= 22) 77% (n=16) 24% (n= 9) Agent used to treat breakthrough pain Tilidine 84% 87% 88% 71% Paracetamol 9% 4% 6% 14% Morphine 2% 0% 6% 0% Ketamine 4% 0% 2% 0% Not documented 1% 9% 0% 15% Allied therapy used Physiotherapy 95% 100% 100% 89% Occupational therapy 85% 97% 100% 68% Speech Therapy 52% 79% 86% 14% Play 9% 7% 27% 0% Music 5% 3% 18% 0% Aromatherapy 2% 3% 9% 0% Primary caregiver at bedside 93% (n= 80) 93% (n= 26) 86% (n= 18) 95% (n= 35) * * * P -Value: Comparison between Carbamazepine and Gabapentin treatment groups only.

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